Infamous 1 & 2(you can get a collection that includes Fesitval of Blood)
Uncharted 1-3
Tomb Raider(I was pleasantly surprised out how well it turned out)
Tomb Raider HD Collection(atleast for Legend & Anniversary, but I also like Underworld)
3D Dot Game Heroes
Anarchy Reigns(haven't beaten it, but it's a neat brawler)
Batman Arkham series(especially if you love Kevin Conroy as Batman, but their great either way)
Back to the Future(neat point & click game, they released a physical version)
Ducktales(physical version comes out in November)
The Lego games are all decent fun, nothing super exciting, but neat all the same)
The 2 Bionic Commando digital games, there's 3D game, some people love it, some hate it
The Bio Shock games, people seem to rave about them, the newest one looks neat
Borderlands 1 & 2, get the GOTY versions
Captain America, it got decent ratings, for some reason, I absolutely loved that game
DC Universe Online is kinda cool, I mostly stuch to the single player stuff
Dragon's Crown
Dungeon Seige 3 if you like newer hack n' slash rpg's
Fallout 3 & New Vegas, however if you do EVERYTHING in Fallout 3, the more glitches you can run into, not sure if Vegas has the same problems, also, the games are loooooooooooooooong, I was somewhere over 200 hours when I finished doing almost every little thing in Fallout 3
GI Joe Rise of Cobra, it's a cool Contra'ish game
Green Lantern Rise of the Manhunters, I totally enjoyed this game, I think it got decent reviews
Heavenly Sword
Ico & Shadow of Collosus Collection
Jak & Daxter Collection
The Incredible Hulk, it's a flawed but still fun open world game loosely based on the most recent movie
Lord of the Rings War in the North
Metal Gear Solid 4 & HD Collection
Midway Arcade Origins
Mirror's Edge
Moon Diver
Outland(if you like Castleroids)
Prototype 1 & 2
Rayman Origins
Red Faction 3 & 4(buy em' cheap, as some especially didn't like 4, which I loved)
Resistance(supposed to be a great series, I haven't played them just yet)
Retro City Rampage(an homage to NES games such as Metal Gear, TMNT, Super Mario, Duck Hunt, etc.)
The Sly Cooper games
Sega Collection
Spiderman Shattered Dimensions & Edge of Time, awesome games(Web of Shadows is good too), haven't played Amazing Spiderman yet
Tales of......if you like the Tales games, there's 1 or 2 out, & there's a collection of 2 games that were GC & Wii exclusives
Transformers(all of them except the first movie game, it's HORRIBLE!) The best ones are Revenge of the Fallen & Fall of Cybertron. If you're a G1 fan like me, I recommend War for Cybertron & Fall of Cybertron
Trinity:Souls of Zill O'll
X-men Destiny
Zone of Ender's HD Collection