My favorite will always be
Super Darius, which I got before my Turbo CD and studied the manual for weeks while waiting for my CD-ROM to arrive.
My unbiased choice would be
Super Darius II, one of the nicest looking 16-bit games around and very balanced for a single screen game with such huge sprites.
Hey, why is the SMS Sagaia lumped together with the GB version?!?
If the SMS version is going to get lumped in with any other, it should be the MD game.