I used to collect GI Joe & Star Wars stuff from 10+ years ago.  I collected a bunch of the newer He-man figures, including King Hssss & the snake men, though, the latest stuff is just too expensive, so, I don't collect those anymore.  There's also various game & anime characters I collected.  Got a nice Vash & Wolfwood, some Mega Man figures, some Samurai Showdown.
I still collect Transformers, basically everything released in stores(no convention stuff) starting from Beast Wars on up.  Around when the first movie came out though, my collecting settled down.  I have a good majority of the first movie figures....but, kind of don't care about them.  I did collect all the TF Animated figures.  That's the last major line I got.  Now I just get the occasional Classics/Generations to have my G1 characters all together, as well as the Masterpiece figures(including Megs).  Though, I don't buy repaints of MP figures, & probably won't get the new release of MP Prime with the trailer, etc.  I get tempted to get some of the Transformer Prime figures, some of them are pretty nice looking, but, I'm just at a point where financially & physically(as in, the space I can fit these figures in) I can't do it anymore.
I do like to pick up alot of anime, old US cartoons(Pac-man, M.A.S.K, Wheelie & the Chopper Bunch, Darkwing Duck, the original TMNT, etc.), & generally any Marvel & DC cartoon series & movie on DVD or Blu Ray(Batman Animated Series, Justice League, Wolverine & the X-men, the recent Avengers cartoon, etc.).  I've been replacing alot of DVD stuff where possible with Blu Ray editions to save space.  For instance, my DBZ movies on DVD, are 2 DBZ movies on Blu Ray(except Broly is all 3 Broly movies).  I also ofcoarse get all series season set of the various Transformers shows.