As much as this game and I are pretty much a perfect fit, I can definitely find some issues with it.
The biggest one I have is certainly the size of the text. The dialogue boxes are fine; but if I'm struggling to read quest details on a 60" TV, there's something wrong there. I do have a slight astigmatism, but even from five feet away I have trouble with this text.
The other issue I have has to do with jumping. It is extremely hard to land precisely off a running jump. That wouldn't bug me so much if it weren't for the fact that the game begs you to explore it vertically even before you get a skell. Having tiny sections of mushroom-like trees in Noctilum that you can stand on, yet hardly ever land on is kind of aggravating.
I also feel mixed on the music. I like a lot of it, but the NLA music is kind of unpleasant. What stinks is that it would be servicable if Sawano just left out the "Uh, uh, yeah," bits.
The rest of the game has felt great to me, although I can understand why it would be frustrating for some. Having story progression locked behind questing is a very "MMO" thing to do, and will annoy people who aren't obsessed with doing everything possible as soon as it becomes available (like me). Some people are also going to hate the combat being wrapped around a hotbar with cooldowns, or the degree with which you have to manage tons of little details to maximize efficiency; but if you enjoyed the original Xenoblade I can't see you having a lot of trouble with this. It feels like a very natural extension of what they did there.
The biggest thing is the story, really. I think some people will love that it takes a back-seat, where others will absolutely hate how typical it is of Japanese story-telling. I've found that the better part of the story seems to be in the quests, but then again I loved the affinity and quest systems in the first Xenoblade too, so take that as you will. It just makes the world feel that much more alive and real to me.
Anyway, I'm sure the game's going to be highly divisive, but as I said before, I think it's the closest I'll get to a game that's a perfect match for me. I am absolutely loving every second spent on Mira.