Reading through this thread just made me realize that I haven't had a hucard played through a stereo in a very long time.  The Duo is pretty much for CD games and the Express is for the hucard games these days.  
The post about R Type reminded me of something funny in the early days of my playing.  I bought a Duo with some CD games first, and it wasn't until a few months later that I bought my first Hucard, R-Type.  Being a big fan of the series, naturally it was awesome. However it made the next few hucards I bought sound like total trash. 
Personal favorites:
R-Type
Parodius (note-I have played the SNES/SFC version and although it has "superior" sound quality, I like the PCE versions of most of the tunes better)
Salamander
Pac Land - no, really.  It only has one song, but I like it.  With the music and the in game sounds playing, it sounds like a whole lot is going on, and it reminds me of an old arcade with all the machines turned up too loud.